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Acid-Base Titration. A laboratory procedure for ascertaining the quantity of either a basic or an acidic substance in solution (q.v.). A liquid reagent of known strength or concentration is added to a measured volume of the solution containing the unknown quantity of a given constituent. The presence of a colored indicator dye (q.v.) serves to define the end point at which neutralization has occurred as disclosed by a change in the indicator's color. From the amount of titrating solution required to attain neutrality, the actual quantity of the dissolved substance present in the sample can be calculated.