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Protein Denaturation

Protein Denaturation. The process whereby water-soluble protein (q.v.) in an aqueous solution, when subjected either to heating or the addition of acids (q.v.), alkalis (q.v.) or neutral salts (q.v.), forms a precipitate that will not redissolve. Denaturation (q.v.) is thought to result from the uncoiling of the originally helical structure of the polypeptide chains (q.v.) under the influence of the heat or other reagents.